cz,I'm thinking of setting up a safe room do you have any "do or don'ts" ?
Shooter32, I am no expert on the subject, as I just learned about them myself when I took the NRA's Personal Protection Inside the Home class last year. But, I don't mind sharing what little I know...because there are lots of others with more knowledge than I on this forum that will chime in (without making me feel like an idiot). That's why this is such a great place to hang out.

Your safe room should be centrally located (like a master bedroom) so that you can get your family to it without exposing them to a threat that may be in the other end of the house. For example...my safe room is my bedroom, which is located between the 2 kid's rooms, connected with a short hallway. If someone comes in the front or back door...I can provide cover at the entrance of the hallway while the kids evacuate to the safe room...I can then retreat to the safe room myself. As my safe room is my bedroom (with a walk-in closet), my gun safes are located in the closet.
The safe room should have an escape route (like a window) in case the BG desides to set the house on fire. If you are on a second story...make sure to have a rope ladder. Make sure everyone knows where to go if evacuation is required. As mentioned before...it should have solid doors with a deadbolt.
Here are a few items I keep in the safe room: cell phone - even an old phone, with no service, can still call 911; flashlight w/ spare batteries; first-aid kit - you may have to deal with an injury in these situations; 12 gauge pump shotgun - if a BG is outside you door, and you work the action of a pump shotgun...it's an unmistakable sound that declares your intention to defend your family (and buckshot is not as likely to make it through several walls and over to the neighbor's house); car remote - if your car has an alarm, and you can activate it from the safe room...use it; house key - make sure there's something highly visible on the key ring (I have a flourescent streamer tied on mine) so the police can find it in the dark.
Once you've retreated to the safe room...CALL 911! Stay on the line with them until the situation is over (even if you have to put the phone down). Everything is recorded. Once the police arrive...chuck the house key out the window and tell the 911 operator where the officer can find the key (so they don't have to kick in the door). Do not come out of the safe room until the 911 operator tells you the officer has cleared the house and is outside the door to the safe room...you don't want the officer to mistake you for the BG, and you don't want the BG to get the jump on you (if they're still inside the house).