In the steaming, swamp that is S. Florida, my little Kel-Tec .380 is with me. Is it the best round for SD? Of course not. Home defense is a complete other story, and short of depleted uranium rds., my house would be a bad choice to attack.
However, the .380 ammo has advanced just like golf balls, cell phones, blu-ray DVD's, HD TV, etc,....Speer, Cor-Bon, Golden Sabre, are a good round.
Remember, the shots won;t take place at a standard happy distance of 7 to 10 yds. The guy jumping your ass in the parking lot of Winn-Dixie will be much closer. Point Blank or 8 to 10 feet renders nasty results with a .380.
It's summertime, take a watermelon out back and stand two feet away and shoot one with a 90gr. Speer GD. JHP, The pieces left are salad size.
They are also carried by many LEO's and others as a BUG. The round works AS INTENDED. The only other MAJOR factor, as with any caliber is SHOT PLACEMENT & PRACTICE.
You can have a Desert Eagle .50, or .44 Magnum,.... if your out of practice, have poor shooting habits, have a lack of situational awareness, think "your the man" and go shoot out back a couple times,... Most BG's don't do any of this. They just have a gun and an attitude problem.
Me and my Walther PPK/S, or Kel-Tec P3AT, that practice ALOT, will surprise any punk ass that tries to take me in the parking lot.
And I will drop them where they stand...
Rant off...