Works great on 22LR. I dunno about the 22 mag....it'd be supersonic and you'd still get the crack...but should be quieter than .223/5.56. I slip a 22 conversion unit into one of the AR's and put rounds through my AAC M4-2000....it works fine! There's a bit more gap having 22 LR inside .223 supressor than having a 22LR supressor. I've shot a 22 LR with a 9mm screwed on then end and it too drops the sound way down...though not like one built for the 22LR. If you are looking for one that does double duty the .223/5.56 will do it but you will have a lot more weight because of the power the .223/5.56 is designed for. It'll weigh down a pistol if you have the right threads/adapter....and be substantially heavier than a regular 22LR supressor which is, at least the lighter ones, aluminum bodied beasties.If you can only have one....I would not mind the .223 at all.
Have you ever had any issues with AAC? I have heard from some trusted friends that their customer service is pretty lacking.