Well, this takes some serious thinking, and I may have to change my mind and repost different list later.... These are in no particular order, BTW.
1- The 1911 {I Also can't pick any particular one of the 4 in my house}. Does it need an explanation? Accurate, Fit the hand well, and it's a .45 ACP which I'm a huge fan of. Pick a handgun accessory, and you can put it or get it on a 1911. Also, it's always been a favorite of my dads. He first taught me to shoot with one of those Marksman BB/dart/pellet guns which is styled closely after a 1911.
2- My Sorely missed, Swear up and down my new year's resolution is to buy it back from the friend I sold it to, Ruger Redhawk .44 Mag. I've been known to shoot it better than most rifles, They're BEAUTIFUL to look at (NOBODY I know of would EVER dare to call a Stainless Ruger Redhawk Ugly.), and with the .44 Mag cartridge and its 7 &1/2 in Barrel, it's legal to hunt big game in any state that will allow handgun hunting. Also, you can kill any game on the North American Continent with it if you got the right load.
3- My New S&W 649. I've wanted one since I was 16; It has a shrouded hammer, which won't snag on the draw, yet unlike the hammerless revolvers, I can still cock to fire it Single action. It hides like a dream in the front pocket of my jeans, and no one knows I have it unless I show them {Or unless they already know me well}, and it's a .357 Magnum. I can use magnum loads OR .38 Special loads in it. One thing it's missing is Crimson Trace Lasergrips, Which I'm saving for.
4- My Glock 30. Lightweight, accurate, and holds 10+1 rounds of .45 ACP, which I'm a huge fan of. Also it's another gun that's easy to find accessories for. I chose it over the G21 because it can use G21 mags as well; also it's more concealable. I also like my G30, because it has a rail, so even though It's a compact pistol, I still can put a TLR-1 on it for Nightstand duty.
5- Choosing a 5th is hard......... BUT, I think I gotta go with my Magnum Research BFR in .45-70. The first reason is It is ALWAYS a crowd pleaser. or letting a friend shWhether you're showing it to family at Thanksgiving or Christmas parties,oot it on your range trip, or just rattling the benches at the local Gun range, People's jaws drop when they see it, and the ground shakes when it goes off. Even though I can't hit all that well with it, I LOVE shooting it.* I also like he fact that you can take out any animal in the world with the cartridge it fires, given the right load, of course.
(*Remember to keep your arms fully extended when firing one.)
YEAH, I have honorable mentions too.......
My Ruger Mark II light target is just so accurate, that You can't hate it {Mine also has lasergrips.}; Untill the first 12 times you have to take it apart and put it back together of course. But once you've learned that you can't hate it.
A Glock 21 is a wonderful thing. the 23 was awesome to shoot. Pretty well any Glock, although I never did like the 36.
Ruger P-series are awesome, however bulky. First gun I ever concealed Carried was a Ruger P90. It wasn't till Is stopped carrying it and tried to carry it again later that I realized how bulky it was. It's Another astoundingly accurate gun. The P85MKII was no different either. Both Tack Drivers.
Any Single Action Revolver.
Walther P38/P1.
One I've never shot, but really want, is a Mare's Leg. Ya know, the Lever action pistols. I want one.
Always wanted a Colt 1917, and have kicked myself for not buying one of the last ones I saw for $450 at the Gun Show. {Shut Up... I was Broke...}
I'll stop here for now........