You didn't give many details of why or where you intend to use it, but a .44 mag that can also use the .44 spl loads is the best "all around" pistol in my eyes.
I'm of "a size" that I can carry a 44 CCW and living in the cooler Pacific NW helps. I previously carryed a S&W 29 with 5" barrel that was way accurate and with the Hogue grips was easily controled even with full house 44 mags. Since I shoot SASS, I now carry a Ruger Blackhawk 6 1/2" barrel, with 44spl's hollow-points or go hiking in the Olympics (black bear country) with 44 mags on board.
With down-loaded 44 spl's it's easy to shoot (much easier than .357mag's), but that HUGE .44 HP will take down anything on two or four legs.