I saw a video online here, sorry I can't find it right now the video page don't got it, where Mr. Pincus shot though several dry wall setups. The wall simulators where set up, I believe, six deep, with each wall four or five feet apart. The .45, .223, slug, and buck penetrated all or near every wall, but the #6 shot only went through one piece of sheet rock and stopped without going all the way through a single wall. An obvious winner, it kept any extremely tight group tight group at a several yards out of a tactical shotgun. It would be very destructive to any intruder in side the home and reduce the chance of over penetration. Like the team said, soft tissue, face, eyes, lungs, heart, even if you don't have any mortal wounds on the first shot, your BG's going down with a half roll of quarters in lead going in him. Follow up shots if you need to. In my defense shot gun for home, I'm running 3" #6 magnums, turkey loads. 40 feet is only ten yards, you should hold a tight group at that and be highly effective. Yeah you want to shoot buck, but I'd play it safe with the family and use a round you know still won't let you down. Reference this video for some ammo info, I found it very informative, they show the power of slug, buck, and bird shot, as well as some exotics.
You may consider prioritizing a load out, similar to LE, by first four rounds #6, and the last rounds using a heavy buck, in case you have to shoot through cover, such as heavy furniture or a vehicle.
Good luck.
http://www.youtube.com/watch?v=ievbU3xIYGQ