The original question was a 1911, well in .460 rowland or .45 super it is definitely capable, if the original question meant a .45 acp, it really does'nt make a difference which handgun it is fired from. I have killed 2 deer with a .45acp. Waited for the correct shot and made it. Should I have done it, yes, We only get so many chances to try our skill in the field, I now know what I can do with what I brought, given it's limitations. Everything else is armchair speculation. Yes those 2 animals dropped within 10 feet. They might not have with different bullet placement. I believe in testing your skill and equipment with everything you have. Yes, if you fail in proper bullet placement, or arrow placement, the game could be lost, that is why we practice, and only take the shot that we know we can make. My personal companion is a Glock 21,,, not that I don't own very nice 1911's. It just seems that it is always with me. And because of that, has more oppurtunity to be shot in the field. It has more kills to it's credit, than any firearm I own, besides my shotguns. 2 deer, 13 raccoons, many cottontails and jackrabbits, 2 really big rattlesnakes, 3 possums and numerous squirrels. Once again, not because it is the most accurate, or powerful, but because it is with me.