When loading handgun ammunition I always lean toward fast burning. I have learned that fast burning gives less felt recoil, maximum speed for load (more efficient in the short barrel of a handgun), and is easier on the eyes when shooing in low or no light.
As long as you follow reloading rules you will have no problem with it. Rules: Follow the recipes as listed by the manufacturer. Changing powders is really no different than changing primers and bullet weights. As long as you stay within chamber pressure specs. you are safe with the gun, and like I said before, I like the benefits of a fast burning powder in handguns.
We have a powder check on our reloader, so over and under charges are caught prior to placing a bullet.