Same diameter bullet as the 5.56/.223 with lighter weight. It's my primary home defense round specifically because it is, I believe, effective and will not overpenetrate walls like the 9mm, .40, .45, etc. and other rounds will. The safety of my children is of paramount concern for me, the deciding factor is intrinsically providing for their safety as innocents and still being able to get the job done as necessary. The round makes nasty wounds in varmints inside 20 yards....animals, though with with less bone mass than humans, being tougher than humans I can't see the round being the least ineffective for home defense.
Maybe it's mystique, but around the range I hang out at it's known as a very effective round in the context of short range use. The research I performed on actual use was sufficient for me to be comfortable with the round. And, at 50 for $20 it's a cheaper alternative than premium self-defense rounds in other pistol calibers.
The 22 mag slow powder burn can't generate 1900+ fps from a short barrel like the 5.7, so the comparison of the two is not an apples to apples comparison. Being a rimless case, magazine (got it right, eh Haz!) feed issues are non-existent. Weapons to chamber it in...the FN Five Seven and PS-90....are both expensive and not easy to find. For such a "rare" round and base of firearms they sure sell a lot of that ammo in the gun shops around town. After a 1000 rounds downrange, neither the Five SeveN pistol or PS-90 have ever had a malfunction.
Low recoil makes it, in my opinion, a very effective tool for women. My wife has it on her side of the bed....and recognizes that a pistol is meant to get you to your rifle..which in her case is a PS-90 in 5.7.
Mr. Pincus and/or Mr. Janich, in your considerate opinions, is the 5.7 x 28 an effective round for home defense?