Brass itself is a "funny" kind of metal. By that I mean it is difficult to achieve consistent hardness from heat to heat. That, combined with the amount of draw steps can result in very hard cartridge brass that, without annealing, can fail on the first firing. The fact the .50 BMG case is thick and long makes this condition worse as far as sealing the chamber at the case neck. That is the main reason you rarely see .50 BMG cases that are not annealed. Some may appear to be, but that is from vigorous tumbling and polishing.
The most consistent, workable brass comes from Lapua. It goes through several heat treatment processes that prevents the metal from over hardening and becoming brittle through the entire drawing process. They are also annealed. They also eliminate stress in the case by drilling the flash hole instead of punching it. It is not at all uncommon for benchrest shooters to reload a single Lapua case 2 dozen times or more. I purchased 200, .308 Lapua cases, and you can tell the difference by how easily they go through a resizing die. Very smooth and effortless, and they require less lubrication as well. I'm told Nosler brass is of very high quality, but as of yet I have not tried it. Bill T.