1. Gun must be easily carried or it will not be carried;
2. Gun must be easily and accurately shot by shooter;
3. Ammunition must be available and affordable for both practice and carry;
4. Gun and ammunition must go bang every time the trigger is pulled and not when it isn't;
5. It must be viewed as a negative by the attacker.
Any gun that goes bang and leaves leaking holes in the body will be a deterrent. Unless your name is Radio Boy, you do not have tattooed across your forehead that it is only a .22 nobody will know you have a small caliber.
I carry a 1911 Gov in .45acp because I can, I like it, and ... Many people are killed by .22lr by self inflicted, accident and intentional. Contrary to popular belief the gangsters that forged the way for today's wanna be punks did not carry big guns. They carried little pocket guns and did just fine murdering with them.
I know what I want and what works for me. You know what you want and what works for you. Refer all others to the list above or similar lists made by people much smarter than me.
But quit ridiculing somebody for their choice of dependable firearm that they will practice with and carry.