The Savage Model 10-ML IS DESIGNED TO HANDLE SMOKELESS POWDER! This is how false stuff gets spread on the Internet. It is the only modern muzzle loader designed to do so. It is the reason people buy it in the first place. What kind of smokeless powder, and how much are what is important! These guns are as safe to fire as any modern weapon with handloaded ammunition. The person doing the loading better know what they are doing. I'm not saying it is the shooters fault, but it very well could be.
Savage 10-ML rifles have been around for a while, and have been proven to be reliable. I'm willing to bet this was 1.) a gross overload. 2.) The wrong type of powder, (too fast). 3.) Any and or all of the above. Yes, it could possibly be a barrel obstruction, or detonation caused by not having the projectile fully seated on the charge, but because of the nature of this type of rifle, I rather doubt it. I'm not much into muzzle loading because of the messy cleanup always involved with these type of guns. But I have considered one of these rifles in the past, and this incident doesn't deter my thinking in the least.
There are dozens of handloading accidents every year that cause injury to shooters. That in itself doesn't alter my thinking about handloaded ammunition. It just makes me all the more careful. A bit like driving slower after you pass a major wreck with injuries on the highway. Bill T.