Need to find how those loads do on the FBI ballistic gelatin test for penetration, expansion and over penetration.
Their standard calls for a minimum penetration of 12 inches. Without that, it doesn't matter how much muzzle energy the round produces, it will not get to vital organs reliably. Granted that the higher the muzzle energy the more likely it will get the required penetration, but it would be good to have that verified objectively.
With expansion, the more the better as long as the penetration is adequate. With .45 rounds, I'd more interested in making sure there was plenty of penetration first.
Penetration over 18 inches is more of a safety issue than a performance issue, however, "they" say that if the bullet leaves the target all the available energy is not delivered to the target. To me, this is a relative concern. If enough energy is delivered to reliably damage the target it is not a major performance problem. I imagine a 50BMG bullet will over penetrate most every human target at self defense ranges but no one is gonna lose sleep over the energy not delivered to the target.
One thing over penetration might indicate is that the round could be just as effective with less muzzle energy.