Hi,
I'm right-handed, but was blinded in my right eye when a teenager. I therefore shoot right-handed and left eyed. I prefer Modified Weaver stance, but Isoceles is OK shooting down the center line of my body. Haven't done much with long arms, (no "bull-pup actions" for me!) but understand the issues of shooting from the left shoulder with a right handed gun.
Now, my Elder's Vision (Presbyopia) has progressed to poor focus on the front sight. I use trifocal glasses because with progressive lenses ("no line" multiple focus points), I am told that I would be scanning constantly like a turtle. Nor can I wear Contact Lenses or have a Lasik procedure done. Each time that I go for a new optical prescription, I measure the distance from my eye to my front sight and tell that to the optometrist to find out the right correction for that distance, having done so, I can than buy inexpensive "drug-store reading glasses" in the right strength for a clear sight picture and then wear them under safety goggles. This works well for target shooting. Otherwise, I would get a kink in my neck tilting my head to use the middle-distance focus of my trifocals, and it's not a good stance.
For potential self-defense, I have enough experience, practice, and muscle-memory to make an accurate shot, but I have added Crimson Trace grips to my .45 Lightweight Commander (and practiced with them) to make a discerning shot under adverse circumstances without glasses. I have also used my prescription dark glasses and dim range light to practice in low light with a Surefire G2 Nitrolon briefly flashed. You want to be able to testify as to your known capabilities in the circumstances of a shooting.
Always make sure that your corrective lenses are polycarbonate safety glasses. Never shoot without some form of safety eyewear (and hearing protection) if you can possibly help it,
i.e., life-or-death. Friends don't let friends shoot without protection. I wear goggles over my glasses to protect them from flying brass or slivers, and to enclose the open sides to keep my eyes safe. (Good glasses aren't cheap, and are certainly worth it.)
My wife is left-handed, but shoots pistol with her right, but with her left eye. Our sons are right-handed with left-eye dominance. Shoot with what works best for you, but always shoot safely and well.
