well, not to take anything from Munden, Miculek or Cisco, but in a gunfight they won't be making as many one shot hits with the targets moving and shooting back (if they live long enough to pull the trigger) and I'd not want to go against these guys with their wheel guns no matter what I was packing.....
But, if it takes more than six shots, they are hurting with a single action. Miculek reloading his swing out is, again, amazingly fast, no doubt faster than most doing a semi reload.
But if you don't have that level of skill with the Wheel Guns are Weal Guns (as Elmer Fudd says

), better learn to get as fast as you can with a semi.