PegLeg,
Congrats to the wife, and enjoy the meat.
What happened with that bullet, and JumboFrank's story are examples that it is as much the bullet as it is the caliber. My .22-250 is a great long range varmint gun, but I have learned to use lightweight hollow points in it. With light hides and little other resistance you need a bullet that will fall apart easily and quickly on fox and coyote. If I use FMJ or even SP, or if I get too heavy the bullet will blow right through without giving the knockdown shock, or just as bad "explode" inside and take all the hide off with the exit hole.
USPSA shooting has done more to educate me for hunting than anything else. Figuring power factors finally turned the light bulb on that made me look at energy. I combined that with what I had learned about bullet characteristics, and I am now much better (not perfect) at picking rounds for animals. The down side is that most stores just stock whatever they think will sell the best, and it can be frustrating trying to find the cartridge you think is really best for your needs.