Would shooting that much +P+ ammo have any negative impact on your pistol? I haven't heard anything about long term use myself.
I'm with Bill on avoiding a steady diet of this on a lightweight frame. For my CZ-75B's...all day long baby...just drop in a spring with an extra 1 or 2 lbs in it no problem. For my M&P's I don't see an issue either...but with only 5-8 thousand rounds through them of "normal" and high pressure ammo there may be issues down the road.