I would offer the suggestion that not only does it depend on your home, it depends on your PLAN. As you probably already know, you should have a plan for different events just as you would for a fire in the house. How you react to a fire in the bedroom might be different than your plan of egress for a fire, say, in the kitchen.
For example, given the layout of my house and the location of my 2-year-old daughter's room relative to mine, if the perp breaks into one of our rooms, I'm going to have my .45 and Surefire in my hands. If he's at the other end of the house, I'll have the .45 in my hand as I get my daughter and retreat into my room so that she and my wife can take cover... Then I am sitting at the end of a dark hallway with my 870 aimed at the first sign of motion at the light end of the hallway. This is one of the reasons that a kitchen light stays on all night.