There could be some concerns. About 90 degrees of gas dispersion area above the bore doesn't exist any more. That is 25%. The design will need to deal with that uneven venting.
Ever seen the guts of a monolithic suppressor. Gasses take all kinds of paths out of the bore.
Manufacturing concerns arise as the baffles are no longer symmetric and alignment will be more critical during assembly and welding.
It depends on the method of manufacturing. Like the monolith mentioned above it is easy to EDM a block to fit inside a tube with non-symmetrical cuts and quicker to manufacture/assemble than multiple components stacked in a conventional suppressor.
Also, this might introduce a heat problem at the top of the can...but I don't know enough to know if it would be any worse than the top of the barrel before the can or if it would affect anything. I guess it could be cooler on top with no hot gases being directed that way....but then the other areas might need to be modified to deal with the increased heat load.
The first two shouldn't affect performance or accuracy, assuming the problems they cause are able to be compensated 100%. They will increase the cost of the product though.
Again it depends on methods of manufacturing (CNC Lathe, EDM Wire, CNC Mill or, my favorite, manually machines), economy of scale (not much to gain here anymore when Lean Manufacturing principles are properly applied) and materials used (Ti vs. 316 SS vs 7071 AL).
I am intrigued in the design differences and I am approaching it from a machinist/manufacturing aspect but I may have to model this up in Solid Works and run the physical simulation on it to see if what we think matches what the computer thinks.