With the exceptions that sighted shooters learn to never point their muzzle at anything they don't intend to shoot, and ID their target and be aware of the background.
Since the blind are by definition incapable of the later they cannot avoid the former.
That leaves just 2 rules for them, all guns are always loaded and keep you booger hook off the bang switch.
And we've see how well that works even, (especially ? ) with Cops.
Since they can't fight at more than contact distances, they can just keep the gun pointing down. Since they can't see what is in front of them they will have no instinct to point it where they are looking..so it is pointed in perhaps the safest direction possible.
And, again, since it will be at point blank range when being physically attacked, they can ID the target as the person at the other end of the arms that are attacking them.
They will not be doing room to room searches and with the their training to keep the gun pointed down unless in physical contact with an assailant, they will be far less likely to be sweeping living or non-living unintended targets...unless you count the floor.
Sure, they can panic and shoot at a noise, just like anyone can panic and shoot at sound or a movement. But, I'd not be surprised if their hearing is more discerning in the dark than our vision is in the dark.