The first thing in my right front pants pocket every morning is a NAA .22LR revolver.
It is there everyday, all day.
It is a back-up to my Glock 27 .40 that goes with me any time I leave the house during our 10 months of summer here in the south. I would prefer my 1911 .45 ACP Commander, but the Glock does conceal better under a plain t-shirt in a Serpa holster. And, it is lighter. When it does get cold enough to wear a jacket, the Commander is there.
The biggest thing I've ever had to use the NAA .22 for is snakes. The first 2 shots are CCI snakeshot, followed by Aguilla high velocity hollowpoints.