I have flown with guns several times, and it is not that difficult. Check out the airlines rules and TSA rules ahead of time, follow the rules to a T, and it will be no worse than any other flight you have ever taken. In several trips the only issue I had was when one airline "small man" decided I had too many guns in one case. I had four guns in four guns in one case; he said that I could put a max of two in a single case; he also said I should put the case inside a suitcase or duffel bag, and that it was ok to put all gun cases in the same duffel; and that TSA should not have allowed me to check them through that way; but he backed down when I held out my "X" airline rule sheets and told him I had flown out there that way.
Pack your gun, pack your ammo, pack your holster, and have a good trip!