As posted, all the brands you listed, make a good .45. So does S&W, EAA, Para, and STI.
I have a Glock21, it's fantastic pistol, you will be better suited to have large hands, and a fantastic carry rig, as it's a big pistol, (I actually call it a rail-road tie with a grip), but it goes bang every time, and is very accurate.
So are the others you listed. "Defend Your Family" covers parameters. At home? On the road?, In the nightstand? Or in a IWB holster.
Kimbers are top shelf, but why spend that much for a pistol, (it's ultimately your choice),...but,.....
Para's come in compact platforms, so do others....Full-size? Mid-size? Recoil management, all come into play.
I can defend my family with my M85 Ultra-Lite .38, as well as a Remington 870, or anything else in my safe, so just getting a .45 will be a personal thing for you.
Have you considered another caliber? Just curious... You asked a brief question that has many possibilities. Take your time, go to gun shows, ranges, retail shops, and browse, fondle, rent, and fire several.
Do you have a lot of .45 exp? 9mm is cheaper ammo, for range time, etc,.... give us some specific things you are looking for in your quest, and I'm sure, those here can help narrow down some choices that will fit what you want.
Let us know, keep us in the loop. It's a big investment, and an important one for you and your family. Good folks here will help anyway we can, and congratulate you on whatever your satisfied with.
Good shopping.
tw