I have a 5" Model 57 Smith .41 Mag...it is my absolute FAVORITE, and I do mean FAVORITE whitetail deer (Michigan variety...big corn fed hummers), and Arizona javelina round. It is a flat-shooting-accurate-as-all-get-out wheel gun, that is easy to pack all day long. That being said....I don't like it for self defense. Over-penetrative for SD, and since I reload my hunting rounds where I WANT more penetration....I don't consider it a first choice for two-legged varmints.
For SD...I will take the .44 Special in a Smith & Wesson, for SD a 180gr LSWHP on top of 7.5gr of Blue Dot for about 900fps. It is easy to shoot all day, and accuracy is phenominal out of my mid-60's vintage Model 24 with a 4" bbl. I find that the LSWHP expands from about 850fps and above in pigs, so, presumably they would also expand just as well in a two-legged varmint.
I do NOT have a problem with using reloads for SD if I am carrying one of my primarily "outdoors guns". Their use in an SD situation would be easily defensible in court even if the prosecution tried to paint me as an evil manufacturer of uber-deadly ammo by simply stating that they were intended for plinking or hunting during the outing, and were only called upon for SD because it was the only ammo I had with me, as it worked in both my lever action carbine, and my revolver, and was intended for the peaceful and recreational shooting I had mentioned before.
That is if, for some reason, I don't have a handy Glock in 9mm through 45ACP.
Still...something about a big ole' thumper in a round thing makes me all warm and fuzzy.