In 410 i would only use slugs. UNLESS you were concerned about something like snakes or mice. On people .410 shot will not be practicle, If some felon is trying to hurt or kill me I do NOT want to hurt or scare him, I want to kill that SOB as rapidly as possible. The .45 LC is the BEST optoin for that, but if you are in a location where over penetration poses an unreasonable risk to other and the range is VERY short, such as an apartment or car on a busy street, the slug will do the job with out going through the threat and hitting someone in the next car or room.