Kmitch200, I'll have to take you task on that one, The .38 special stands up to more than mild or harsh examination, it is inherently accurate, tuneable to exceptional accuracy. Now the original poster said centerfire cartridge, that would not be true, if you include rifles or bottle neck cases. But as a pistol round it is exceptional in the accuracy department. I guarantee you will spend a thousand or more bucks to beat a 6" model 14 S&W, with factory ammo and someone who nows how to shoot at 50 yards.
I have a 2x scoped Model 29, 5" gun that with 300 grain Hornaday xtp's, will shoot target accuracy, 2.5" at 50 yards and 4-5' at one hundred yards, took a lot of developement to get there. .38 spl Anemic? Yes, but not bad with modern loads, and the accuracy is always there with a quality pistol, I'm not a Colt revolver fan, but the Diamond back will shoot this well, the Python too.
I have shot more than 130,000 rounds of .38 special, from standard and light loads to loads that make IPSC major, with 158 grain bullets, shot in a .357 chamber of course. I shoot PPC, master rating, NRA action shooting, master rating, Hunters Pistol, large bore, AAA rating, ICORE expert rating. Shot revolvers in .38 spl in all of the them.
There are many accurate calibers, but I would put the 38 special above the rest for out of the box, with out of the box ammo.
Best gun for the trail? It rates, but I personally like more power, a .357 mag is very useful, especially with a pocket full of 148 grain, full 38 spl wadcutters for small game, quiet, accurate and cuttiing a full .357 hole.