I have a Beretta Neos. I bought it because I've read the manuals for the Ruger and decided that I didn't want something that complicated. I love the toolless takedown of the Neos and I love the magazine release, which is located on the right side of the firearm, above and slightly behind the trigger, where your finger rests when you're not shooting. I've never had it accidently activate, but I've got less than 500 rounds through it.
I have a problem with my Neos though. I likes to jam during feeding. I've tried several different types and I want to try some Federal Automatch from Midway. That might fix it. I hope it's because it's a new gun and not because it's something I should have stayed away from.
I also have a Ruger Single Six, which does exactly what it was designed to do. It came with a .22 Mag cyclinder as well, but that cyclinder fits a little tighter and with less than 30 rounds through it, issues with the cyclinder timing occurred. I hope this will work itself out, because when I switched back to the .22lr cyclinder, it ran like a bunny.