I have one of the S&W made Walther PPK's in .380. It's a nice small gun but it's heavy for the size and worse than that it has sharp edges and corners.
Unlike Mr. Bane, I not only acknowledge my Dremel Limitations I adhere to them.

I generally carry it in an ankle holster when I carry it. As far a being .380...that's just a 9mm short with a lighter bullet.
My everyday carry is a 9MM because it's lighter and more concealable. I don't perceive the difference in bullet performance as large a factor as say the 1) ability to conceal 2) ability to control and 3) capacity versus the 45 or the 40.
If I knew I was going to do battle with drugged out ISIS guys in the sandbox I'd go with the 45 hands down...or more likely a 10MM 1911 like Kimber makes. Ditto for a backup for hog and bear hunting.
As far as bullets wearing a gun out...after several thousand rounds out of a 45 M&P and a 1911 versus several thousand each out of 9MM M&P, CZ's, FN's, etc. I dunno if that is a big factor. By the time you wear out a 40 or a 45...if it wears out first, you'll be able to buy a 9MM on the savings.
For me the 9MM works better for everyday conceal.
Also, if pinched for cash, the savings can be invested in a 22 LR pistol of similar construct to your primary carry and used for training. Now, I say a 22 LR because the biggest boost I get in gun handling is when I train with my centerfire weapon and a 22 side by side. Every so often I swap from centerfire to 22 with the reduced recoil and catch myself pickup up old bad habits of anticipating recoil, improper trigger control, etc. The more I train with the 22 the less often I have too!
My 2 cents.