My neighbor, Pete, has seven or eight handguns....four cap and ball wheelguns, and three or four "ca'tridge sixguns". His carry gun is a Uberti "bird's head" 3-inch "Sheriff's Model" in .45 Colt.
Now, Pete is 58 years old, and some MAY say he is set in his ways. I have seen him shoot that old-timey smoke wagon. He hits what he aims at, and does it in a pretty rapid fashion, thumbing the hammer with his off hand.
I made him a concealable OWB holster with a matching 6-round loop ammo carrier.
Sure, his wheelgun is old-fashioned. It doesn't load fast. But, in the end...he is damned good with it, and I don't think he is he least bit under armed.
Would a thumb buster be MY first or second choice? Nope. But it works for him.