Hello. To me, it is a dilemma like "Ginger or Mary Ann?" (Just kidding!)
I actually am fond of both .44 Special and .45 Colt revolvers. At the present time, I own waaaay too few of either, having so foolishly let several examples in each caliber "get away". Right now I own but one Taurus Model 431 3" in .44 Special along with a S&W Model 24 w/6.5" bbl and solitary 4" S&W Mountain Gun in .45 Colt.
Here is my 431 (bottom) with my 3" Ruger GP100. (I wish Ruger would offer that very configuration in a 5-shot .44 Special?)
This is my only S&W Model 24 and is my favorite S&W revolver just to shoot, a V E R Y close second being a Model 14. This revolver was legally-used to "harvest" (kill) Texas whitetail deer in a state-sanctioned management program. Using 240-gr. SWC handloaded to just under 1000 ft/sec, or 180-gr. Hornady XTP's at about 1150 ft/sec, no deer required more than one shot. Either load offered "plenty" and only "sure" shots were taken; any doubt whatsoever and the shot was passed. I killed a total of 7 deer with that revolver, the farthest shot being right at 27 yards, broadside and the deer standing still.
This S&W Mountain Gun in .45 Colt has been just a peach of a fun revolver. I've taken a few deer with this one as well, usually using a 250-gr. SWC at about 900 ft/sec. Probably the most "potent" thing I've shot through it has been Corbon's DPX round, but its main "diet" remains handloaded SWC's at about 900 ft/sec or so. They group plenty tightly enough for me and are potent enough to handle anything in Texas that might need "handling" in my opinion. I have been unable to tell any difference in effect on whitetails from about 85-lbs to about 140-lbs when hit with any of the mentioned .45 Colt or .44 Special loads. When smacking the animal just behind the shoulder, about 1/3 of the way from the bottom of the chest cavity, they jump, run no more than 50 yards or so (usually less) and fall. A few have run right into trees, which might indicate that blood loss was already bringing on vision-failure. Keep in mind that a deer can cover this short distance in but a few seconds, waaaaay less than the "dead man's 10 seconds".Between the two cartridges, I prefer the .44 Special but by a very narrow margin. I cannot really offer anything all that logical as to why...only that I do. That said, I sure wouldn't whine if the "Gun God" decreed, "No more .44 Specials for you, heathen. You will only shoot these vintage S&W .45 Colt caliber revolvers"...but I am simple-minded and easily amused; I even like .38 Specials!
Best to all.