Great post on this subject this morning, Michael. I agree with you: If you've carefully selected your .22s to be as close to your "real guns" as possible, everything is exactly the same except the recoil.
However, that is significant. I've found that when training with a .22, you MUST make a conscious effort to grip and hold the gun (especially a handgun) exactly the same way you would if it were a CF. With reduced .22 recoil, it's very easy over time to slip into the bad habit of laxing up your grip or stance. Every time you get a sight picture, remind yourself to "grip down" on the thing.
Another tip: Some of us will plan to shoot a few hundred .22s in a session, followed by 50 (or 100 or 20 or whatever number) of "the real thing" centerfire ammo. This (IMHO) is doing it backwards. START your session with the centerfire, which will serve as a reminder of what the "real gun" will do and how you need to practice good grip and stance througout your whole session.