My first hunting handgun was a Ruger Single Six .22 (and .22 magnum). I then added a single action American Western Arms - Longhorn .357. Next came the S&W 22a with a Burris red dot. The 22a was traded this winter for a second Ruger Mark III Competition Target that is getting redone for hunting and steel. My current big game handgun, replacing the .357, is a S&W 500 PC. This gun is waiting for an optic that I haven't decided on yet and can't afford yet, however I am able to pound a 20 lb. lp tank at 100 yards off hand and 150 to 200 yards off a rest all day with iron sights. Note - All day does not mean boxes and boxes of ammo. After 25 - 30 rounds in an hour my elbows have had their limit for the day.
Just like picking a caliber, action and optic in rifle hunting, handgun choices are dictated by what you are after and personal preferences. I like my .22's for little critters, and I have taken fox at about 35 yards with well placed shots. I have taken whitetails with the .357, but in our area where we can't use rifles for deer I like the range the 500 gives me.
I suggest you make a list of what you want to do with the gun (what game and what range), what options you want with it (optics, holster, and carry preference), if hunting a wide variety do you want one gun or different guns for different game and situations, and do you want a gun that is forgiving or one that tests your skills (a .22 requires marksmanship, where a .357 will give you a little forgiveness, and the 500 will knock most anything off their feet by just breezing the lead past them). Talk to hunters, ask us on here (scary thought right there), and look at what is available ... Did I mention price?
For me the research and prep is just as enjoyable as the actual hunting itself. Hours, days, weeks and months of reading, talking to hunters, and thinking about what I want to do followed by many hours of practice with the gun is all just fore play ... Now I know why she likes that so much
