Really? At least one of those 22WMR pocket revolvers.....
But seriously, although ammo is sporadic, but around and pricey, the .380 is the way to go. My Walther PPK, and Kel-Tec, WILL do the job if you have practice, training, practice, training.
So will the the little 22WMR, really wouldn't consider the 22lr for SD, unless it's the last of the last resort.
Cor-Bon DPX are great for the .380, as well as the Speer Gold Dot. & Golden Sabre, although the price sucks. It's a great SD round.