Things like car navigation systems, and Mapquest are for people who are anal about folded maps but don't want to be bothered doing it right.
The most passing glance at a map will usually show you the most direct route to somewhere, then just refold the map so that section is showing and to hell with the factory creases,
Someplace like the Bay area or LA a "Thomas Guide" is worth it's weight in gold, it lists and shows EVERY street in the area it covers.
I think people who can not handle a road map DESERVE to be lost.