My wife loved my P-220 in .45, it fit well and recoiled less than her S&W 645.
I suggest you find a range that rents pistols and take her shooting and let HER decide which she likes best. I tried to push various weapons on the wife early on and discovered that women are different. . .Even more different, than I thought. Did you know that the S&W SW380 was nearly unusable for women with long nails due to the mag release? I didn't, but the wife pointed it out.
We men tend to project our own likes and dislikes onto our women instead of simply providing advice and depending on them to make a good decision.
I concur with the Warhawke. Men...women...we are wired differently and have a different perspective and different needs. The fingernail example is one of the finest examples of a difference in "why" that can be made...and that is a valid concern...I wouldn't make fun of my wife (again) for the same thing! ! ! (Of course, Warhawke, if you wanted to live dangerously you could be dumb like me and tell her to cut those nails....see where that get's you...HA!).
The only thing I would really push, is for initial gun use experiences to be low recoil, low muzzle blast events...and that would be something like a .22 or .38 cowboy loads...so I believe you are right to initially gravitate to low power loads. Wired differently or not, she'll want to "prove herself" after she gains confidence and move up to the higher powered rounds on her own, if shooting is something she fancies.
Squibby is on the mark too. A few more coins, but the Tacsol barrels are "the bomb". She'll undoubtably love the colors first, the light weight second...my wife doesn't like plain blued barrels, stainless steel, plain wood grips and especially not synthetic stocks/grips....which is why I spent a bunch of money on a Taurus Titanium anodized blue, with a faux pearl handle and gold hammer/trigger combination. Lady Smith has some neat looking products too.... There's an upside for buying her something from Tacsol...have you ever seen the really cool camo 10/22's???...I'm just saying you know, just saying that if you get her something from Tacsol how can she say no to you getting something from Tacsol?
ATTENTION CRIMSON TRACE: From above, "...my wife doesn't like plain blued barrels, stainless steel, plain wood grips and especially not synthetic stocks/grips....".
My wife won't give up her faux pearl grips. She desperately wants a laser....but the
laser is second to fashion! Can ya'll help us out here?