The defensive advantage of the sound of racking a shell is overrated ... unless you are a movie producer.
#1. I agree that the safeties on a shotgun are not as good as a handgun, so one in the closed chamber is not the best idea;
#2. A fun of any kind should never be just leaned - build or buy a rack that the gun will hang in or lean in securely;
#3. Full magazine, one in chamber with action open - Just slide pump forward or hit release on semi-auto and you are ready.
An unloaded gun is only a club, so if you are not going to keep it very easy to use it will be worthless when you are aroused at 2:15 AM. A gun that is stored in an unsecured way is poor practice since not only may it fall over with normal household activity, but it could very easily be knocked over in the act of putting it into use.
Just like setting yourself up to carry a gun, setting your shotgun up in the bedroom will require lots of trial and error and lots of practice. There have been many threads on this forum discussing carry guns and holsters. The common thought is that it is finding the right one that puts more handguns either in the safe or used as trade material, and why we all have the standard "box of holsters." Good luck, and enjoy the quest!