Bluebullet,
I don't know how experienced you are with automatics, but I would not rule out a revolver for home defense. I have a S&W M19 that has served me well for decades, including a tour in Vietnam. It has the advantage of being always ready and easy to operate. When I lived in Thailand my only gun was a S&W M36 which went every where with me.
I have also used a M1911, M1911A1, P226, P239, and a P220 as bedroom shelf guns. I like them all but you still can't beat the S&W revolver at home. I don't think they still make the lovely M19 but there are good revolvers out there and you should at least consider them.
There are those who advocate a shotgun or some sort of carbine for home defense as well. I like the M1 carbine, based on experience with an M2 in combat. I would not feel bad these days with a Rock River AR, but it stays in the safe for use as a target rifle.
BTW at the moment my bedroom gun is a SIG P220R with night sights, laser max sights, and attached flashlight. But I am afraid the .45 might be too loud in the house.
You also need to think about muzzle flash wrecking your night vision.
Pioneer461 was right about opinions. Good luck in your quest and let us know what you wind up doing.