I've been told when using a mouse gun (.380 or less) going for a head shot is the best course.
I expect most encounters where I will be using my LCP, I probably wont have much time to take a head shot. If I do have time, I'll likely have time to present the G23 and then I'm not using a mouse gun any more...excepting the views of the .45ACP crowd

If I do have the time, I'll take that advice if I can, but I do expect my target to be at the end of my left arm....if I'm lucky.