Being in NJ we would only fire in self defense on our property or home and 99% probably in the home. Here we also have the duty to retreat, so we would naturally retreat to the closest gun. Problem is, that's usually not somewhere where there's maneuvering room, so no choice as to which DIRECTION you can engage.
Having said all that, we have softened all of our loads in the home. The shotty has birdshot, the 357 and 45 is Critical Defense (HP with plastic insert), the 9mm is frangible ball. We try to minimize through-wall penetration. NJ is a little hinky about regular HP ammo too. it's legal, but if they somehow determine that you were not 100% in the right, then all of a sudden you used HP in a "crime" and you're screwed, so we try to avoid straight HP.