I was in this same boat as i have medium to large hands. I found the PPS felt terrible in my hand. The Glock had too much forward tilt to the grip, that left me choosing between an XD and M&P both in a compact .40 variety. I went with the M&P simply because of my love for S&W, but the XD is just as good and probably a few bucks cheaper.
But as has been mentioned before, nothing can subsitute for trigger time in firearm choosing.