I would not try it, unless it was all I had, and had not choice, but Ted Nugent killed a water buffalo with one, but he hammered it multiple times until it fell down.
I'll use my G20 for most anything here in TX, 300lbs and under should do fine, with a good shot, ammo choice, and common sense. I do load mine above industry standards, with brand new brass, not to be loaded that hot again.!! I won't give out my loads, but 800x, is the powder of choice.