Yikes, 100 yards with a handgun. That sounds like a challenge.
I only see the 225gr LeveRevolution ammo. Looking at the trajectory charts, if it's 2.4" high at 50 yards, then it should be dead on at 100 yards. Am I looking at that right? That's nice, if it holds it's trajectory that well.
Not a lot of folks down here hunting with 44 mags, nor pistols to boot. For deer, a lot of 7mm mags, 30-30, 30-06, etc.
I would definitely use a rest.

When I had 20-something eyes and steadier hands (and I could afford more practice ammo) I could keep all my shots in a fair group at 100 yds freehand with 200gr bullets at around 1200 fps using a Ruger SBH with a 4 5/8" barrel.
Those days are loooooong gone. Not that I don't still have the potential, I just don't shoot the big bores at those distances enough any more to reliably take game free-handed. I have padded rests mounted in the windows of my deer blind.
With the LeverEvolution and a 7 1/2" barreled SBH....from a steady rest, I can still keep 'em in the kill zone.
Most of the shots I could possibly take on game is in wooded areas where <75 yds would be the norm.